Skip Navigation



MBE Advance Access published online on May 6, 2009
Molecular Biology and Evolution, doi:10.1093/molbev/msp096
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
26/8/1823    most recent
msp096v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wall, J. D.
Right arrow Articles by Plagnol, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wall, J. D.
Right arrow Articles by Plagnol, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Detecting ancient admixture and estimating demographic parameters in multiple human populations

Jeffrey D. Wall1,*, Kirk E. Lohmueller2 and Vincent Plagnol3

1 Institute for Human Genetics and Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA
2 Department of Molecular Biology and Genetics and Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY
3 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, United Kingdom

* Address for correspondence: Jeff Wall, Institute for Human Genetics, UCSF, 513 Parnassus Ave., S965, San Francisco, CA 94143, Phone: 415-476-4063, Email: wallj{at}humgen.ucsf.edu

Received for publication October 30, 2008. Revision received March 7, 2009. Accepted for publication April 18, 2009.

We analyze patterns of genetic variation in extant human polymorphism data from the NIEHS SNPs project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations), and by explicitly estimating the amount of putative admixture between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, H. floresiensis). We find evidence for this ancient admixture in European, East Asian and West African samples, suggesting that admixture between diverged hominin groups may be a general feature of recent human evolution.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.