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MBE Advance Access published online on March 19, 2009
Molecular Biology and Evolution, doi:10.1093/molbev/msp053
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Lowly expressed human microRNA genes evolve rapidly

Han Liang and Wen-Hsiung Li

Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA

Corresponding author: Li, W.-H. (Email: whli{at}uchicago.edu)

Received for publication October 2, 2008. Revision received March 5, 2009. Accepted for publication March 10, 2009.

To study the evolution of human miRNAs, we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ~30% of currently annotated human miRNA genes are almost free of selective pressure.


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