Skip Navigation



MBE Advance Access published online on October 29, 2008
Molecular Biology and Evolution, doi:10.1093/molbev/msn246
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
26/2/285    most recent
msn246v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brochier-Armanet, C.
Right arrow Articles by Gribaldo, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brochier-Armanet, C.
Right arrow Articles by Gribaldo, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

The multiple evolutionary histories of dioxygen reductases: implications for the origin and evolution of aerobic respiration

Celine Brochier-Armanet1,3,*, Emmanuel Talla2,3 and Simonetta Gribaldo4,*

1 Université de Provence Aix-Marseille I, France
2 Université de la Méditerranée Aix-Marseille II, France
3 Laboratoire de Chimie Bactérienne CNRS UPR9043, Marseille, France
4 Unité de Biologie Moléculaire chez les Extremophiles (BMGE), Institut Pasteur, Paris, France

* Corresponding authors Céline Brochier-Armanet, celine.brochier{at}ibsm.cnrs-mrs.fr, Laboratoire de Chimie Bacterienne (CNRS - UPR9043), |Institut de Biologie Structurale et de Microbiologie, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 20, FRANCE, Phone 33491164508, Fax 33491718914, Simonetta Gribaldo, simo{at}pasteur.fr, Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Département de Microbiologie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15

Received for publication July 17, 2008. Revision received October 10, 2008. Accepted for publication October 22, 2008.

Understanding the origin and evolution of cellular processes is fundamental to understand how biological activity has shaped the history of our planet. Among these, aerobic respiration is probably one of the most debated. We have applied a phylogenomics approach to investigate the origin and evolution of dioxygen reductases (O2Red), the key enzymes of aerobic respiratory chains. The distribution and phylogenetic analysis of the four types of O2Red (Cyt-bd, and the A-, B- and C- families of haem copper O2Red) from 673 complete bacterial and archaeal genomes shows that these enzymes have very different evolutionary histories: Cyt-bd are of bacterial origin and were transferred to a few archaea; C-O2Red are of proteobacterial origin and were transferred to a few other bacteria; B-O2Red are of archaeal origin and were transferred to a few bacteria; A-O2Red are the most ancient dioxygen reductases and were already present prior to the divergence of major present-day bacterial and archaeal phyla, thus before the emergence of Cyanobacteria and oxygenic photosynthesis. Implications for the origin and the evolution of aerobic respiration are discussed.

Key Words: Dioxygen reductases • Aerobic respiration • Horizontal gene transfer • Phylogenomics • Cytochrome c oxidases • Cytochrome bd


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Schoepp-Cothenet, C. Lieutaud, F. Baymann, A. Vermeglio, T. Friedrich, D. M. Kramer, and W. Nitschke
Menaquinone as pool quinone in a purple bacterium
PNAS, May 26, 2009; 106(21): 8549 - 8554.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.