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MBE Advance Access published online on September 23, 2008
Molecular Biology and Evolution, doi:10.1093/molbev/msn212
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© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Regulation dynamics of WGD genes during yeast metabolic oscillation

Hong Chen1, Lin Xu2 and Zhenglong Gu1,*

1 Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853
2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853

* To whom correspondence should be addressed. Z.G. (zg27{at}cornell.edu)

Saccharomyces cerevisiae and its close relatives are characterized by their propensity to ferment even in the presence of oxygen. It was hypothesized that whole genome duplication (WGD) led to the development of this efficient fermentative life style (WGD-Fermentation hypothesis, Piskur, 2001). In this study, we found that a significantly higher proportion of WGD genes than non-WGD genes are dynamically regulated during metabolic oscillation in response to oxygen change. The same dataset also shows that the WGD genes, as compared to the smaller-scale duplicate (SSD) genes, are enriched with pairs where both copies have cyclic expression during the metabolic oscillation (either with the same or different phases). These results provide new evidences for the WGD-Fermentation hypothesis and new insights into the relationship between genome duplication and the evolution of new life styles in eukaryotic organisms.

Key Words: WGD • yeast • metabolic cycling genes • WGD-Fermentation hypothesis


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