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MBE Advance Access published online on August 22, 2008
Molecular Biology and Evolution, doi:10.1093/molbev/msn186
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© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species

Mohamed A. F. Noor

Biology Department, Duke University

Correspondence: M. Noor, Biology Department, Box 90338, Duke University, Durham, NC 27708 USA, Telephone: 919-613-8156, FAX: 919-660-7293, E-mail: NOOR{at}DUKE.EDU

Received for publication July 30, 2008. Revision received August 19, 2008. Accepted for publication August 19, 2008.

Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombination and sequence divergence between species. Because recombination is mutagenic in yeast, I evaluate this assay by testing whether noncoding DNA sequence divergence between Saccharomyces species is related to measures of meiotic double-strand DNA breaks or crossover rates derived from S. cerevisiae. Contrary to expectation, I find that sequence divergence is either uncorrelated or negatively correlated with rates of both double-strand break and crossover. Several caveats are mentioned, but these results suggest that mutagenesis from meiotic recombination is not the primary driver of sequence divergence between Saccharomyces species. This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity.

Key Words: recombination • divergence • diversity • Saccharomyces


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