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MBE Advance Access published online on May 28, 2008
Molecular Biology and Evolution, doi:10.1093/molbev/msn124
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Published by Oxford University Press 2008.

Research Article

The Impact of Founder Events on Chromosomal Variability in Multiply Mating Species

John E. Pool1 and Rasmus Nielsen1

1 Department of Integrative Biology, University of California, Berkeley

Corresponding author: John E. Pool, Department of Integrative Biology, University of California, Berkeley, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA, 94720-3140, United States, Tel: +1-510-642-1233. Fax: +1-510-643-6264. E-mail: jpool{at}berkeley.edu

Received for publication March 14, 2008. Revision received May 15, 2008. Accepted for publication May 21, 2008.

In species with heterogametic males, the relative levels of X chromosome versus autosome diversity hold key information about the evolutionary forces at work in a population. It has been shown that population size changes alter the ratio of X-linked to autosomal (X/A) variation, with population size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect - that of founder events involving multiply mated females - and find that it leads to much stronger reductions in X/A diversity ratios than are produced by simple population size changes. Investigating the potential of this process to account for sharply reduced X-linked diversity in European Drosophila melanogaster, we find that this model yields predictions that are compatible with the empirical data.

Key Words: Founder events • multiple mating • X-linked variation • autosomal variation • Drosophila melanogaster


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