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MBE Advance Access published online on December 10, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm269
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Selective Sweeps in a Two-Locus Model for Sex-Ratio Meiotic Drive in Drosophila simulans

Nicolas Derome*,{dagger},§, Emmanuelle Baudry{ddagger}, David Ogereau§, Michel Veuille* and Catherine Montchamp-Moreau§

* Ecole Pratique des Hautes Etudes, Paris, France
{dagger} Current affiliation: Université Laval, Québec, Canada
{ddagger} Ecologie, Systématique et Evolution, CNRS UMR8079, Université Paris-Sud 11, 91405 Orsay, France
§ Laboratoire Evolution Génome et Spéciation, UPR9034, CNRS 91198 Gif-sur Yvette Cedex, France and Université Paris-Sud 11, 91405 Orsay Cedex, France Gif-sur-Yvette, France

Corresponding Author: Michel Veuille, Ecole Pratique des Hautes Etudes, Unité mixte de Recherche CNRS 5202 (C 39), département Systématique et Evolution, Muséum National d'Histoire Naturelle, 16 rue Buffon, 75005 Paris, France, veuille{at}mnhn.fr, tel : 331 40793327, fax 331 40793337

Received for publication July 6, 2007. Revision received October 27, 2007. Accepted for publication November 1, 2007.

A way to identify loci subject to positive selection is to detect the signature of selective sweeps in given chromosomal regions. It is revealed by the departure of DNA polymorphism patterns from the neutral equilibrium predicted by coalescent theory. We surveyed DNA sequence variation in a region formerly identified as causing sex-ratio meiotic drive in Drosophila simulans. We found evidence that this system evolved by positive selection at two neighboring loci, which thus appear to be required simultaneously for meiotic drive to occur. The two regions are approximatively 150 kb distant, corresponding to a genetic distance of 0.1 cM. The presumably large transmission advantage of chromosomes carrying meiotic drive alleles at both loci has not erased the individual signature of selection at each locus. This chromosome fragment combines a high level of linkage disequilibrium between the two critical regions with a high recombination rate. As a result, two characteristic traits of selective sweeps - the reduction of variation and the departure from selective neutrality in haplotype tests - show a bimodal pattern. Linkage disequilibrium level indicates that, in the natural population from Madagascar used in this study, the selective sweep may be as recent as 100 years.

Key Words: meiotic drive • sex ratio • selective sweep • Drosophila simulans


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