Skip Navigation



MBE Advance Access published online on November 20, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm256
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
25/2/310    most recent
msm256v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Coyle, S.
Right arrow Articles by Kroll, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coyle, S.
Right arrow Articles by Kroll, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Starvation induces genomic rearrangements and starvation-resilient phenotype in yeast.

Scott Coyle

(UC Berkeley), Molecular Sciences Institute, University of Montana

Evgueny Kroll

Health Sciences 301, Department of Biologocal Sciences, University of Montana, 32 Campus Dr, Missoula MT 59812, phone number: 5108477813, FAX number: 212-659-0765

Evgueny Kroll, (corresponding author) current address: email: evgueny.kroll{at}mso.umt.edu

Received for publication August 5, 2007. Revision received November 12, 2007. Accepted for publication November 14, 2007.

Evolution has shaped a wide variety of genomes across eukaryotic taxa. However, the forces that shape the genomes are generally unknown. Since organisms in nature commonly experience prolonged periods of nutrient depletion, we posit that diverse demographic, physiological and genomic responses to starvation can occur. To test for these possibilities, we subjected replicate yeast populations to prolonged starvation. We observed that clones repeatedly gave rise to descendants that were karyotypically diverse. After a one-month starvation period, approximately 70% of randomly isolated members of starved populations harbored one or more genomic rearrangements. Further we found that 5 out of 16 karyotypically-differentiated groups of isolates from starved populations were more resilient to starvation than non-starved clones and their common ancestor. Phylogenetic analysis of these isolates suggests that genomic rearrangements which arose during starvation can be adaptive in the context of a nutrient-depleted environment. Altogether our data illustrate the profound influence of environmental conditions on adaptive genome evolution in eukaryotes.

Key Words: genome rearrangements • starvation • Saccharomyces cerevisiae • genome evolution


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.