Skip Navigation



MBE Advance Access published online on April 17, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm073
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Material
Right arrow Supplementary Material
Right arrow All Versions of this Article:
24/7/1458    most recent
msm073v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liu, Q.-X.
Right arrow Articles by Gojobori, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, Q.-X.
Right arrow Articles by Gojobori, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Compensatory Change of Interacting Amino Acids in the Coevolution of Transcriptional Coactivator MBF1 and TATA-Box Binding Protein TBP

Qing-Xin Liu*,1, Naomi Nakashima-Kamimura{dagger},1, Kazuho Ikeo*, Susumu Hirose{dagger} and Takashi Gojobori*

* Center for Information Biology and DNA Data Bank of Japan
{dagger} Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan

Corresponding author: Takashi Gojobori, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan, E-mail: tgojobor{at}genes.nig.ac.jp, Tel: 81-55-981-6847, Fax: 81-55-981-6848.

Received for publication April 3, 2006. Revision received July 26, 2006. Revision received December 19, 2006. Revision received February 24, 2007. Accepted for publication March 15, 2007.

To elucidate the transcriptional regulation in eukaryotic genome network, it is important to understand coevolution of transcription factors, transcriptional coactivators and TATA-box binding protein TBP. In this study, coevolution of transcriptional coactivator MBF1 and its interacting target TBP was first evaluated experimentally by examining if compensatory amino acid changes took place at interacting sites of both proteins. The experiments were conducted by identifying interaction sites and comparing the amino acids at these sites among different organisms. Here we provide evidence for compensatory changes of transcription coactivator and its interacting target, presenting the first report that transcription coactivator may have undergone coevolution with TBP.

Key Words: Compensatory change • coevolution • transcriptional coactivator • MBF1 • TBP

1 These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.