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MBE Advance Access published online on March 8, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm051
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Is There Evidence for Convergent Evolution Around Human Microsatellites?

Matthew T. Webster1,* and Jonas Hagberg2

1 Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland
2 Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden

* Corresponding author Present address: Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden. Email: matthew.webster{at}ebc.uu.se, Tel: +46 18 471 6444

Received for publication February 15, 2007. Accepted for publication February 28, 2007.

A study by Vowles and Amos (2004) identified atypical patterns of base composition around human microsatellites and argued that microsatellites generate mutational biases in their flanking regions. Here we perform simulations of molecular evolution using a simple model that suggest similar patterns can be produced without any such biases in genome evolution.

Key Words: microsatellite • convergent evolution • simulation • genome evolution • mutation bias


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