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MBE Advance Access published online on February 24, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm032
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster

Dorcas J. Orengo and Montserrat Aguadé

Departament de Genètica, Facultat de Biologia, Universitat de Barcelona

Corresponding author: Dorcas J. Orengo, Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645 Edifici Annex 2a planta, 08028 Barcelona, Spain. Tel (34)93 403 53 04 Fax (34)93 403 44 20, Email : dorcasorengo{at}ub.edu

Received for publication October 19, 2006. Revision received February 13, 2007. Accepted for publication February 16, 2007.

Nucleotide variation in populations originating from the recent range expansion of a species should reflect their adaptation to new habitats as well as their demographic history. A survey of nucleotide variation at 109 non-coding X-chromosome fragments in a European population of Drosophila melanogaster allowed identifying some candidates to have been recently affected by positive selection. Adaptive changes leave a spatial differential footprint that can be used to discriminate among candidates by extending their study to neighboring regions. Here, we surveyed variation at an ~190-kb region spanning a locus exhibiting a significantly skewed frequency spectrum. A stretch of ~12 kb with reduced variation was detected within a continuously sequenced region that included the focal fragment. Moreover, the regions flanking this stretch exhibited an excess of high-frequency derived variants. Application of maximum-likelihood ratio and goodness-of-fit tests suggested that the pattern of variation detected at the studied region (at cytological bands 17C-17D) might have been shaped by a recent selective change, most probably at or around the phantom (phm) gene that encodes CYP306A1, a cytochrome P450 enzyme in the ecdysteroidogenic pathway.

Key Words: Drosophila melanogaster • nucleotide polymorphism • positive selection


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