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MBE Advance Access published online on January 11, 2007
Molecular Biology and Evolution, doi:10.1093/molbev/msm004
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

No Evidence for an mtDNA Role in Sperm Motility: Data From Complete Sequencing of Asthenozoospermic Males

Luísa Pereira1,2, João Gonçalves3, Ricardo Franco-Duarte1, Júlia Silva3, Tiago Rocha4, Christiane Arnold4, Martin Richards5 and Vincent Macaulay6

1 IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), R. Dr. Roberto Frias s/n, 4200-465 Porto, Portugal
2 Medical Faculty, University of Porto, Portugal
3 Centro de Genética Humana Instituto Nacional de Saude Dr. Ricardo Jorge, Lisboa, Portugal
4 Maternidade Dr. Alfredo da Costa, Lisboa, Portugal
5 Institute of Integrative & Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
6 Department of Statistics, University of Glasgow, Glasgow G12 8QQ, United Kingdom

Corresponding Author: Luísa Pereira, IPATIMUP, R. Dr. Roberto Frias s/n, 4200-465 Porto, PORTUGAL, Phone: +351 22 5570700, Fax: +351 225570799, Email: lpereira{at}ipatimup.pt

Accepted for publication January 3, 2007.

The first complete mitochondrial DNA (mtDNA) sequences (~16,569bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mitochondrial DNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

Key Words: mtDNA • complete sequences • asthenozoospermia • association


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