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MBE Advance Access published online on August 4, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msl078
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted July 31, 2006

Letter

The Hidden Value of Missing Genotypes

William Amos 1 *

1 Department of Zoology, Downing Street, Cambridge, CB4 3DB, UK

* To whom correspondence should be addressed.
William Amos, E-mail: w.amos{at}zoo.cam.ac.uk


  Abstract

Robotic systems allow vast genetic datasets to be generated automatically with little manual input, raising questions about accuracy. To test whether errors occur randomly, I used the frequencies of missing genotypes in a large human dataset to construct a population tree. Remarkably, the gaps appear to carry as strong a phylogenetic signal as the actual data themselves.

Keywords: human population; microsatellite; null alleles; genetic distance; genotyping error.
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