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MBE Advance Access published online on July 25, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msl069
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted June 23, 2006

Research Article

Evidence of Gene Conversion Associated With a Selective Sweep in Drosophila melanogaster

Sascha Glinka 1 *, David De Lorenzo 1, and Wolfgang Stephan 1

1 Section of Evolutionary Biology, Department of Biology II, Ludwig-Maximilians University, 82152 Planegg-Martinsried, Germany

* To whom correspondence should be addressed.
Sascha Glinka, E-mail: glinka{at}zi.biologie.uni-muenchen.de


  Abstract

Since Drosophila melanogaster colonized Europe from tropical Africa 10 to 15 thousand years ago, it is expected that adaptation has played a major role in this species in recent times. A previously conducted multi-locus scan of non-coding DNA sequences on the X chromosome in an ancestral and a derived population of D. melanogaster revealed that some loci have been affected by directional selection in the European population. We investigated if the pattern of DNA sequence polymorphism in a region surrounding one of these loci can be explained by a hitchhiking event. We found strong evidence that the studied region around the gene unc-119 was shaped by a recent selective sweep, including a valley of reduced heterozygosity of 83.4 kilobases, a skew in the frequency spectrum, and significant linkage disequilibrium on one side of the valley. This region, however, was interrupted by gene conversion events leading to a strong haplotype structure in the center of the valley of reduced variation.

Keywords: Drosophila melanogaster; nucleotide diversity; gene conversion; selective sweep.
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D. J. Orengo and M. Aguade
Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster
Mol. Biol. Evol., May 1, 2007; 24(5): 1122 - 1129.
[Abstract] [Full Text] [PDF]


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