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MBE Advance Access published online on June 6, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msl031
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted June 1, 2006

Letter

Positive Selection Versus Demography: Evolutionary Inferences Based on an Unusual Haplotype Structure in Drosophila simulans

Humberto Quesada 1 *, Sebastián E. Ramos-Onsins 2, Julio Rozas 2, and Montserrat Aguadé 2

1 Departamento de Bioquímica, Genética e Inmunología, Facultad de Ciencias, Universidad de Vigo, 36200 Vigo, Spain; Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
2 Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain

* To whom correspondence should be addressed.
Humberto Quesada, E-mail: hquesada{at}uvigo.es


  Abstract

Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of D. simulans displaying an unusual large-scale haplotype structure. The multilocus analysis, based on summary statistics using specific demographic null models under recombination, indicates that the observed levels of linkage disequilibrium (LD) differed significantly from the values expected under different bottleneck and population admixture scenarios. These results indicate that demography alone may not account for the observed pattern of variation, and support the previous claim that the data are better described by a model in which an adaptive mutation has not yet gone to fixation.

Keywords: Drosophila; selective sweep; coalescent simulations; bottleneck; population admixture.
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