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MBE Advance Access published online on April 18, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msk024
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted April 7, 2006

Letter

Evidence that Protein Length Expansion and Contraction is Partly Owing to Mutational Events in Pre-meiotic Cells

Suzanne Bowen 1 and Alan E. Wheals 1 *

1 Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY

* To whom correspondence should be addressed.
Alan E. Wheals, E-mail: bssaew{at}bath.ac.uk


  Abstract

Studies on the rate of evolution of proteins typically concentrate on rates of change of orthologous amino acids rather than changes in size (i.e. generation of non-orthologous domains). Recent work has focused attention on Ser/Thr-rich regions in yeast as these tend to undergo size changes rapidly, with size polymorphisms commonly being found, especially in proteins with cell surface localisation. The underlying mechanism generating the indels is presently unclear though, due to a lack of correlation with the location of meiotic double-strand breaks, it has, by exclusion, been conjectured to be replication slippage. Here we provide new evidence to support this possibility. Notably we show that Ser/Thr-rich repeat regions are more generally associated with the location of Mre11p in pre-meiotic cells. This we argue is to be expected were the repeats produced by mutational events in mitotic cells possibly through replication slippage.

Keywords: Replication slippage; Ser/Thr-rich; polymorphisms; yeast.
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