Skip Navigation



MBE Advance Access published online on March 17, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msk003
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
23/6/1192    most recent
msk003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Braasch, I.
Right arrow Articles by Meyer, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Braasch, I.
Right arrow Articles by Meyer, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted March 9, 2006

Research Article

Asymmetric Evolution in Two Fish-Specifically Duplicated Receptor Tyrosine Kinase Paralogons Involved in Teleost Coloration

Ingo Braasch 1, Walter Salzburger 2, and Axel Meyer 3 *

1 Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Germany; Current address: BioFuture Research Group "Evolutionary Fish Genomics", Physiological Chemistry I, Biozentrum, University of Würzburg, Germany
2 Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Germany; Center for Junior Research Fellows, University of Konstanz, Germany
3 Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Germany

* To whom correspondence should be addressed.
Axel Meyer, E-mail: axel.meyer{at}uni-konstanz.de


  Abstract

The occurrence of a fish-specific genome duplication (FSGD) in the lineage leading to teleost fishes is widely accepted, but the consequences of this event remain elusive. Teleosts, and the cichlid fishes from the species flocks in the East African Great Lakes in particular, evolved a unique complexity and diversity of body coloration and color patterning. Several genes involved in pigment cell development have been retained in duplicate copies in the teleost genome after the FSGD. Here we investigate the evolutionary fate of one of these genes, the type III receptor tyrosine kinase (RTK) colony-stimulating factor 1 receptor (csf1r). We isolated and shotgun sequenced two paralogous csf1r genes from a bacterial artificial chromosome (BAC) library of the cichlid fish Astatotilapia burtoni that are both linked to paralogs of the pdgfr gene, another type III RTK. Two pdgfr -csf1r paralogons were also identified in the genomes of pufferfishes and medaka and our phylogenetic analyses suggest that the pdgfr -csf1r locus was duplicated during the course of the FSGD. Comparisons of teleosts and tetrapods suggest asymmetrical divergence at different levels of genomic organization between the teleost-specific pdgfr -csf1r paralogons, which seem to have evolved as co-evolutionary units. The high evolutionary rate in the teleost B-paralogon, consisting of csf1rb and pdgfr b, further suggests neofunctionalization by functional divergence of the extracellular, ligand-binding regions of these cell-surface receptors. Finally, we hypothesize that genome duplications and the associated expansion of the receptor tyrosine kinase family might be causally linked to the evolution of coloration in vertebrates and teleost fishes in particular.

Keywords: genome duplication; fish; pigmentation; csf1r; pdgfr; cichlid.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
M. G. Mills, R. J. Nuckels, and D. M. Parichy
Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes
Development, March 15, 2007; 134(6): 1081 - 1090.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.