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MBE Advance Access published online on March 13, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msk001
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted March 6, 2006

Research Article

Homologs of Mitochondrial Transcription Factor B, Sparsely Distributed within the Eukaryotic Radiation, are Likely Derived from the Dimethlyadenosine Methyltransferase of the Mitochondrial Endosymbiont

Timothy E. Shutt 1 and Michael W. Gray 1 *

1 Program in Evolutionary Biology, Canadian Institute for Advanced Research, and Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada

* To whom correspondence should be addressed.
Michael W. Gray, E-mail: m.w.gray{at}dal.ca


  Abstract

Mitochondrial transcription factor B (mtTFB), an essential component in regulating the expression of mitochondrial DNA-encoded genes in both yeast and humans, is a dimethyladenosine methyltransferase (DMT) that has acquired a secondary role in mitochondrial transcription. So far, mtTFB has only been well studied in Opisthokonta (metazoan animals and fungi). Here we investigate the phylogenetic distribution of mtTFB homologs throughout the domain Eucarya, documenting the first examples of this protein outside of the opisthokonts. Surprisingly, we identified putative mtTFB homologs only in amoebozoan protists and trypanosomatids. Phylogenetic analysis together with conservation of intron positions in amoebozoan and human genes supports the grouping of the putative mtTFB homologs as a distinct clade. Phylogenetic analysis further demonstrates that the mtTFB is most likely derived from the DMT of the mitochondrial endosymbiont.

Keywords: mitochondrial transcription; mtTFB; endosymbiont; dimethyladenosine transferase.
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