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MBE Advance Access published online on February 28, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msj116
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted February 24, 2006

Letter

Microsatellite Variation, Repeat Array Length and Population History of Plasmodium vivax

M. Imwong 1, D. Sudimack 2, S. Pukrittayakamee 1, L. Osorio 3, J.M. Carlton 4, N.P.J. Day 5, N.J. White 5, and T.J.C. Anderson 2 *

1 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
2 Southwest Foundation for Biomedical Research (SFBR), San Antonio, Tx, USA
3 International Centre for Medical Research and Training (CIDEIM), Cali, Colombia
4 The Institute for Genomic Research, Rockville, Md, USA
5 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Vaccinology, Churchill Hospital, Oxford, UK

* To whom correspondence should be addressed.
T.J.C. Anderson, E-mail: tanderso{at}darwin.sfbr.org


  Abstract

A recent paper (Leclerc et al. 2004) described limited variation in di-nucleotide microsatellites from P. vivax, suggesting very recent bottlenecks or genome wide selective events. We describe patterns of variation in 11 di-nucleotide microsatellites in Plasmodium vivax populations from Colombia, India and Thailand. We find abundant variation with heterozygosity of 0.64, 0.76 and 0.77 respectively in the 3 countries. The discrepancy between these two studies results is simply explained by the differences in the size of repeat arrays. The microsatellites studied by Leclerc et al have very few repeats (median 5.5, range 4-13) so would not be expected to be variable. P. vivax microsatellites show comparable levels of variation to those in P. falciparum when repeat array length is taken into account and provide no support for recent bottlenecks or widespread selective purging of variation from the genome of P. vivax.

Keywords: Microsatellite; array length; heterozygosity; selection; bottleneck.
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