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MBE Advance Access published online on January 11, 2006
Molecular Biology and Evolution, doi:10.1093/molbev/msj090
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted December 21, 2005

Research Article

The Evolutionary Rate of a Protein is Influenced by Features of the Interacting Partners

Takashi Makino 1 and Takashi Gojobori 1 *

1 Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Yata 1111, Mishima 411-8540, Japan

* To whom correspondence should be addressed.
Takashi Gojobori, E-mail: tgojobor{at}genes.nig.ac.jp


  Abstract

Rates of protein evolution are thought to be influenced by features of protein-protein interaction. However, the most important features of interaction for determining evolutionary rate are poorly understood. Here we consider four categories for protein-protein interactions in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function (SF) or different function (DF), and the extent to which these interactions involve connections in the dense part (DP) or sparse part (SP) of a protein-protein interaction network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.

Keywords: Protein-protein interaction; Functional module; Saccharomyces cerevisiae; Evolution.
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