Skip Navigation



MBE Advance Access published online on December 27, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msj086
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
23/4/721    most recent
msj086v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Salathé, M.
Right arrow Articles by Bonhoeffer, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salathé, M.
Right arrow Articles by Bonhoeffer, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted December 15, 2005

Letter

The Effect of Multi-functionality on the Rate of Evolution in Yeast

Marcel Salathé 1 *, Martin Ackermann 1, and Sebastian Bonhoeffer 1

1 Ecology & Evolution, ETH Zürich, ETH-Zentrum NW, CH 8092 Switzerland

* To whom correspondence should be addressed.
Marcel Salathé, E-mail: marcel.salathe{at}env.ethz.ch


  Abstract

Multifunctional genes are expected to evolve at lower rates because mutations in such genes that improve one function might often have deleterious effects on other functions. Here we tested for an association between multi-functionality and evolutionary rates in genes of Saccharomyces cerevisiae, and we find a highly significant negative correlation between the number of biological processes in which a gene is involved in and its rate of evolution. However, the magnitude of this effect is small, and the results do not support the notion that multi-functionality limits a gene's rate of evolution.

Keywords: pleiotropy; dN/dS; evolutionary genomics; rate of evolution.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
X. He and J. Zhang
Toward a Molecular Understanding of Pleiotropy
Genetics, August 1, 2006; 173(4): 1885 - 1891.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.