Skip Navigation



MBE Advance Access published online on December 16, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msj078
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
23/3/683    most recent
msj078v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sun, C.
Right arrow Articles by Zhang, Y.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sun, C.
Right arrow Articles by Zhang, Y.-P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted December 13, 2005

Research Article

The Dazzling Array of Basal Branches in the mtDNA Macrohaplogroup M from India as Inferred from Complete Genomes

Chang Sun 1 #, Qing-Peng Kong 1 #, Malliya gounder Palanichamy 2 #, Suraksha Agrawal 3 #, Hans-Jürgen Bandelt 4, Yong-Gang Yao 5, Faisal Khan 3, Chun-Ling Zhu 5, Tapas Kumar Chaudhuri 6, and Ya-Ping Zhang 7 *

1 Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
2 Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China
3 Department of Medical Genetics, Sanjay Gandhi Institute of Medical Sciences, 226014 Lucknow, India
4 Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
5 Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
6 Department of Zoology, North Bengal University, Siliguri West Bengal, India
7 Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China

* To whom correspondence should be addressed.
Ya-Ping Zhang, E-mail: zhangyp1{at}263.net.cn


  Abstract

Many efforts based on complete mitochondrial DNA (mtDNA) genomes have been made to depict the global mtDNA landscape, but the phylogeny of Indian macrohaplogroup M has not yet been resolved in detail. To fill this lacuna, we took the same strategy as in our recent analysis of Indian mtDNA macrohaplogroup N and selected 56 mtDNAs from over 1,200 samples across India for complete sequencing, with the intention to cover all Indian autochthonous M lineages. As a result, the phylogenetic status of previously identified haplogroups based on control-region and/or partial coding-region information, such as M2, M3, M4, M5, M6, M30, and M33, was solidified or redefined here. Moreover, seven novel basal M haplogroups (viz. M34-M40) were identified and yet another five singular branches of the M phylogeny were discovered in the present study. The comparison of matrilineal components among India, East Asia, Southeast Asia, and Oceania at the deepest level yielded a star-like and non-overlapping pattern, reflecting a rapid mode of modern human dispersal along the Asian coast after the initial "Out-of-Africa" event.

Keywords: mitochondrial DNA; India; haplogroup M; complete sequence; phylogeny.

#These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Petraglia, C. Clarkson, N. Boivin, M. Haslam, R. Korisettar, G. Chaubey, P. Ditchfield, D. Fuller, H. James, S. Jones, et al.
Population increase and environmental deterioration correspond with microlithic innovations in South Asia ca. 35,000 years ago
PNAS, July 28, 2009; 106(30): 12261 - 12266.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Powell, S. Shennan, and M. G. Thomas
Late Pleistocene Demography and the Appearance of Modern Human Behavior
Science, June 5, 2009; 324(5932): 1298 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
Q. D. Atkinson, R. D. Gray, and A. J. Drummond
mtDNA Variation Predicts Population Size in Humans and Reveals a Major Southern Asian Chapter in Human Prehistory
Mol. Biol. Evol., February 1, 2008; 25(2): 468 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
F. Zhang, B. Su, Y.-p. Zhang, and L. Jin
Genetic studies of human diversity in East Asia
Phil Trans R Soc B, June 29, 2007; 362(1482): 987 - 996.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. W. Carter
Mitochondrial diversity within modern human populations
Nucleic Acids Res., May 25, 2007; 35(9): 3039 - 3045.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Hudjashov, T. Kivisild, P. A. Underhill, P. Endicott, J. J. Sanchez, A. A. Lin, P. Shen, P. Oefner, C. Renfrew, R. Villems, et al.
Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis
PNAS, May 22, 2007; 104(21): 8726 - 8730.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
U Roostalu, I Kutuev, E-L Loogvali, E Metspalu, K Tambets, M Reidla, E. Khusnutdinova, E Usanga, T Kivisild, and R Villems
Origin and Expansion of Haplogroup H, the Dominant Human Mitochondrial DNA Lineage in West Eurasia: The Near Eastern and Caucasian Perspective
Mol. Biol. Evol., February 1, 2007; 24(2): 436 - 448.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Olivieri, A. Achilli, M. Pala, V. Battaglia, S. Fornarino, N. Al-Zahery, R. Scozzari, F. Cruciani, D. M. Behar, J.-M. Dugoujon, et al.
The mtDNA Legacy of the Levantine Early Upper Palaeolithic in Africa
Science, December 15, 2006; 314(5806): 1767 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Q.-P. Kong, H.-J. Bandelt, C. Sun, Y.-G. Yao, A. Salas, A. Achilli, C.-Y. Wang, L. Zhong, C.-L. Zhu, S.-F. Wu, et al.
Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations
Hum. Mol. Genet., July 1, 2006; 15(13): 2076 - 2086.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.