Skip Navigation



MBE Advance Access published online on December 20, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msj076
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
23/3/479    most recent
msj076v2
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by DeBarry, J. D.
Right arrow Articles by McDonald, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DeBarry, J. D.
Right arrow Articles by McDonald, J. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted December 12, 2005

Letter

The Contribution of LTR Retrotransposon Sequences to Gene Evolution in Mus musculus

Jeremy D. DeBarry 1, Eric W. Ganko 2, and John F. McDonald 3 *

1 Department of Genetics, University of Georgia, Athens, GA 30602 USA
2 Department of Genetics, University of Georgia, Athens, GA 30602 USA; Present address: Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280
3 Department of Genetics, University of Georgia, Athens, GA 30602 USA; Present address: School of Biology, Georgia Institute of Technology, Atlanta, GA 30332

* To whom correspondence should be addressed.
John F. McDonald, E-mail: john.mcdonald{at}biology.gatech.edu


  Abstract

Approximately 1.5% of mouse genes (Mus musculus) contain LTR retrotransposon sequences (LRS). Consistent with earlier findings in C. elegans, D. melanogaster and H. sapiens, LRS are more likely to be associated with newly evolved genes. Evidence is presented that LRS are often recruited as novel exons or as spliced additions to existing exons. These novel gene configurations may be expressed initially as alternative transcripts providing an opportunity for the evolution of new gene function(s).

Keywords: LTR retrotransposon; gene evolution; Mus musculus; mouse.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Xue, A. P. Rooney, M. Kajikawa, N. Okada, and W. L. Roelofs
Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion
PNAS, March 13, 2007; 104(11): 4467 - 4472.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.