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MBE Advance Access published online on August 24, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msi241
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Accepted August 4, 2005

Research Article

Gene Conversion and the Evolution of Three Leucine-Rich-Repeat Gene Families in A. thaliana

Mariana Mondragon-Palomino 1* and Brandon S. Gaut 2

1 Department of Ecology and Evolutionary Biology, University of California in Irvine, Irvine 92697 U.S.A; Present Address: Mariana Mondragón Palomino, Department of Genetics, Friedrich Schiller Universität, Philosophenweg 12, Jena 07743. Germany. Telephone: +49-3641-949-556. Fax: +49-3641-949-552
2 Department of Ecology and Evolutionary Biology, University of California in Irvine, Irvine 92697 U.S.A

* To whom correspondence should be addressed.
Mariana Mondragon-Palomino, E-mail: mariana.mondragon{at}uni-jena.de


  Abstract

The high number of duplicated genes in plant genomes provides a potential template for gene conversion and unequal crossing-over. Within a gene family these two processes can render all members homogeneous or generate diversity by reassorting variants among paralogs. The latter is especially feasible in families where gene diversity confers a selective advantage and thus conversion events are likely to be retained. Consequently the most complete record of gene conversion is expected to be most evident in gene families commonly subjected to positive selection. Here we describe the extent and characteristics of gene conversion and unequal crossing-over in the coding and non-coding regions of NBS-LRR, Receptor-Like Kinases (RLK) and Receptor-Like Proteins (RLP) in the plant Arabidopsis thaliana. Members of these three gene families are associated with disease resistance and their pathogen recognition domain is a documented target of positive selection. Our bioinformatic approach to study the major family features that may influence gene conversion revealed that in these families there is a significant association between the occurrence of gene conversion and high levels of sequence similarity, close physical clustering, gene orientation and recombination rate. We discuss these results in the context of the overlap between gene conversion and positive selection during the evolutionary expansion of the NBS-LRR, RLK and RLP gene families.

Keywords: Gene conversion; gene family; positive selection; Leucine-Rich Repeat (LRR); Arabidopsis thaliana.
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