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MBE Advance Access published online on June 29, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msi206
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Accepted June 24, 2005

Research Article

Gene Expression Evolves Faster in Narrowly than in Broadly Expressed Mammalian Genes

Jing Yang 1, Andrew I. Su 2, and Wen-Hsiung Li 1*

1 Department of Ecology and Evolution, University of Chicago, Chicago, Illinois
2 Genomics Institute of the Novartis Research Foundation, San Diego, California

* To whom correspondence should be addressed.
Wen-Hsiung Li, E-mail: whli{at}uchicago.edu


  Abstract

Despite much recent interest, it remains unclear what determines the rate of evolution of gene expression. To study this issue we develop a new measure, called "Expression Conservation Index" (ECI), to quantify the degree of tissue expression conservation between two homologous genes. Applying this measure to a large set of gene expression data from human and mouse, we show that tissue expression tends to evolve rapidly for genes that are expressed in only a limited number of tissues, whereas tissue expression can be conserved for a long time for genes expressed in a large number of tissues. Therefore, expression breadth is an important determinant for evolutionary conservation of tissue expression. In addition, we find a rapid decrease in ECI with the synonymous divergence between duplicate genes, suggesting fast divergence in tissue expression between duplicate genes.

Keywords: gene expression evolution; expression conservation; duplicate genes; transcription factors.
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