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MBE Advance Access published online on June 8, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msi189
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Accepted June 1, 2005

Letter

Positive Correlation Between Evolutionary Rate and Recombination Rate in Drosophila Genes with Male-Biased Expression

Zhi Zhang 1 and John Parsch 1*

1 Department of Biology II, Section of Evolutionary Biology, University of Munich (LMU), Munich, Germany

* To whom correspondence should be addressed.
John Parsch, E-mail: parsch{at}zi.biologie.uni-muenchen.de


  Abstract

Previous studies have shown that genes that are expressed predominantly or exclusively in males tend to evolve rapidly in comparison to other genes. In most cases, however, it is unknown whether this rapid evolution is the result of increased positive (or sexual) selection on male-expressed traits or if it is due to a relaxation of selective constraints. To distinguish between these two possibilities, we analyzed the relationship between the nonsynonymous substitution rate (dN) and local recombination rate for 343 Drosophila genes that were classified as male-, female-, or non-sex-biased in their expression. For the male-biased genes, a positive correlation between dN and recombination rate was observed. This can be explained by an increased rate of adaptive evolution in regions of higher recombination due to a reduction of Hill-Robertson interference. In contrast, the correlation between dN and recombination rate was negative for both female-, and non-sex-biased genes, suggesting that these genes are primarily subject to purifying selection, which is expected to be less effective in regions of reduced recombination.

Keywords: Adaptive evolution; Hill-Robertson interference; sex-biased genes.
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