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MBE Advance Access published online on March 9, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msi127
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Accepted February 28, 2005

Research Article

Reduced MIC Gene Repertoire Variation in West African Chimpanzees as Compared to Humans

Natasja G. de Groot 1*, Christian A. Garcia 2, Ernst J. Verschoor 1, Gaby G.M. Doxiadis 1, Steven G.E. Marsh 2, Nel Otting 1, and Ronald E. Bontrop 1

1 Department of Comparative Genetics and Refinement, and Virology, Biomedical Primate Research Centre, The Netherlands
2 Anthony Nolan Research Institute and, Royal Free and UCL School of Medicine, Royal Free Campus, London, UK

* To whom correspondence should be addressed.
Natasja G. de Groot, E-mail: groot{at}bprc.nl


  Abstract

The human major histocompatibility complex class I chain-related (MIC) genes are members of a multicopy family showing similarity to the classical HLA-A, -B, and -C genes. Only the MICA and B genes produce functional transcripts. In chimpanzees, however, only one MIC gene is expressed, showing an intermediate character, resulting from a deletion fusing the MICA and B gene segments together. The present population study illustrates that all chimpanzee haplotypes sampled possess the hybrid MICA/B gene. In contrast to the human situation this gene displays reduced allelic variation. The observed repertoire reduction of the chimpanzee MICA/B gene is in conformity with the severe repertoire condensation documented for Patr-B locus lineages, probably due to the close proximity of both genes.

Keywords: Chimpanzee; humans; HIV; MHC; MIC.
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