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MBE Advance Access published online on February 16, 2005
Molecular Biology and Evolution, doi:10.1093/molbev/msi113
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Accepted February 8, 2005

Research Article

The Pattern of Nucleotide Difference at Individual Codons among Mouse, Rat, and Human

Robert Friedman 1 and Austin L. Hughes 1*

1 Department of Biological Sciences, University of South Carolina, Columbia SC 29208 USA

* To whom correspondence should be addressed.
Austin L. Hughes, E-mail: austin{at}biol.sc.edu


  Abstract

The patterns of nucleotide difference were compared at 3,473,111 codons from 9,390 aligned orthologous genes of mouse (Mus musculus), rat (Rattus norvegicus), and human (Homo sapiens). The results showed evidence of a higher frequency of both synonymous and nonsynonymous differences from human in the rat than in the mouse. However, contrary to a previous report, there was no evidence of a greater frequency of codons with multiple nonsynonymous substitutions between the two rodent species than expected under random substitution.


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