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MBE Advance Access published online on December 22, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msi072
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Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved.
Accepted December 20, 2004

Letter

Comparative Genomics of Centrality and Essentiality in Three Eukaryotic Protein-Interaction Networks

Matthew W. Hahn 1* 1 and Andrew D. Kern 1 1

1 Center for Population Biology, University of California, Davis, California 95616, USA

* To whom correspondence should be addressed.
Matthew W. Hahn, E-mail: mwhahn{at}ucdavis.edu


  Abstract

Most proteins do not evolve in isolation, but as components of complex genetic networks. Therefore, a protein's position in a network may indicate how central it is to cellular function, and hence how constrained it is evolutionarily. In order to look for an effect of position on evolutionary rate, we examined the protein-protein interaction networks in three eukaryotes: yeast, worm, and fly. We find that the three networks have remarkably similar structure, such that the number of interactors per protein and the centrality of proteins in the networks have similar distributions. Proteins that have a more central position in all three networks, regardless of the number of direct interactors, evolve more slowly and are more likely to be essential for survival. Our results thus are consistent with a classic proposal of Fisher's that pleiotropy constrains evolution.

Keywords: networks; pleiotropy; constraint; natural selection.

1The authors contributed equally to this work


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