Skip Navigation



MBE Advance Access published online on December 1, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msi059
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Correction to PDF
Right arrow All Versions of this Article:
22/3/716    most recent
msi059v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bayona-Bafaluy, M. P.
Right arrow Articles by Moraes, C. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bayona-Bafaluy, M. P.
Right arrow Articles by Moraes, C. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Accepted November 9, 2004

Research Article

Fast Adaptive Co-evolution of Nuclear and Mitochondrial Subunits of ATP Synthetase in Orangutan

Maria Pilar Bayona-Bafaluy 1, Stefan Müller 2, and Carlos T. Moraes 3*

1 Department of Neurology, University of Miami School of Medicine, Munich, Germany
2 Institute for Anthropology and Human Genetics, Department Biology II, Ludwig-Maximilians University, Munich, Germany
3 Department of Neurology, University of Miami School of Medicine, Munich, Germany; Department of Cell Biology & Anatomy, University of Miami School of Medicine, Munich, Germany

* To whom correspondence should be addressed.
Carlos T. Moraes, E-mail: cmoraes{at}med.miami.edu


  Abstract

Nuclear and mitochondrial genomes have to work in concert to generate a functional oxidative phosphorylation (OXPHOS) system. We have previously shown that we could restore partial OXPHOS function when chimpanzee or gorilla mitochondrial DNA (mtDNA) were introduced into human cells lacking mtDNA. However, we were unable to maintain orangutan mitochondrial DNA in a human cell. We have now produced chimpanzee, gorilla, orangutan and baboon cells lacking mtDNA and attempted to introduce mtDNA from different apes into them. Surprisingly, we were able to maintain human mtDNA in an orangutan nuclear background, even though these cells showed severe OXPHOS abnormalities, including a complete absence of assembled ATP synthetase. Phylogenetic analysis of Complex V mtDNA-encoded subunits showed that they are among the most evolutionarily divergent components of the mitochondrial genome between orangutan and the other apes. Our studies showed that adaptive coevolution of nuclear and mitochondrial components in apes can be fast and accelerate in recent branches of anthropoid primates.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NeuroscientistHome page
M. F. Casanova and C. R. Tillquist
Encephalization, Emergent Properties, and Psychiatry: A Minicolumnar Perspective
Neuroscientist, February 1, 2008; 14(1): 101 - 118.
[Abstract] [PDF]

Home page
 Hum Mol GenetHome page
M. Ingman and U. Gyllensten
Rate variation between mitochondrial domains and adaptive evolution in humans
Hum. Mol. Genet., October 1, 2007; 16(19): 2281 - 2287.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.