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MBE Advance Access published online on October 13, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msi014
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
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Accepted October 4, 2004

Research Article

Non-African Origin of a Local Beneficial Mutation in D. melanogaster

F. Catania 1 and C. Schlötterer 1*

1 Institut für Tierzucht und Genetik, University of Wien, Josef Baumann Gasse 1, 1210 Wien, Austria

* To whom correspondence should be addressed. E-mail: christian.schloetterer{at}vu-wien.ac.at.


  Abstract

It is well understood that the out of Africa habitat expansion of D. melanogaster was associated with the fixation of many beneficial mutations. Nevertheless, it is not clear yet, whether these beneficial mutations segregated already in Africa or originated outside of Africa. In this report we describe an ongoing selective sweep specific to one European population. One microsatellite allele has increased in a population from The Netherlands to a frequency of 18%, while it is virtually absent in 12 other European populations. The selective sweep resulted in a genomic region of more than 600kb that is identical by descent. This is probably the first evidence of a beneficial mutation that has arisen outside of Africa and has resulted in a selective sweep localized in a population from The Netherlands.

Keywords: local adaptation; allele frequency; microsatellite; partial selective sweep.
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