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MBE Advance Access published online on April 14, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msh139
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
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Accepted March 18, 2004

Original Articles

Mutations Induced by Ancient DNA Extracts? Letter

D. Serre 1, M. Hofreiter 1, S. Pääbo 1*

1 Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Germany

* To whom correspondence should be addressed. E-mail: paabo{at}eva.mpg.de.


  Abstract

We have investigated whether some factor in ancient DNA extracts induces site-specific mutations in modern DNA as described by Pusch and Bachmann (2004). We find no evidence for higher mutation rates when extracts from three different Pleistocene mammals are added to modern DNA than when water or extraction blanks are added. We also fail to find evidence that any such factor affects ancient DNA sequences determined from the same extracts. This as well as the patterns of nucleotide substitutions seen in DNA sequences determined from hundreds of other specimens leads us to doubt that a previously unknown mutagenic factor can be a general feature of extracts from old tissues.

Key Words: Ancient DNA, mutagenesis, contamination


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