Skip Navigation



MBE Advance Access published online on March 24, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msh135
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
21/7/1361    most recent
msh135v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dupanloup, I.
Right arrow Articles by Barbujani, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dupanloup, I.
Right arrow Articles by Barbujani, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Accepted March 5, 2004
© 2004 Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved.

Original Articles

Estimating the Impact of Prehistoric Admixture on the Europeans' Genome

Isabelle Dupanloup 1, Giorgio Bertorelle 1, Lounès Chikhi 2, and Guido Barbujani 1*

1 Dipartimento di Biologia, Università di Ferrara, via L. Borsari 46, I-44100 Ferrara, Italy
2 UMR 5174 Evolution et Diversité Biologique, Université Paul Sabatier, UMR Evolution et Diversité Biologique, 118 Route de Narbonne F-31062 Toulouse cédex 4, France

* To whom correspondence should be addressed. E-mail: g.barbujani{at}unife.it.


  Abstract

We inferred past admixture processes in the European population from genetic diversity at eight loci, including autosomal, mitochondrial and Y-linked polymorphisms. Admixture coefficients were estimated from multilocus data, assuming that most current populations can be regarded as the result of a hybridization process among four or less potential parental populations. Two main components are apparent in the Europeans' genome, presumably corresponding to the contributions of the first, Paleolithic Europeans, and of the early, Neolithic farmers dispersing from the Near East. In addition, only a small fraction of the European alleles seems to come from North Africa, and a fourth component reflecting gene flow from Northern Asia is largely restricted to the North-East of the continent. The estimated Near Eastern contribution decreases as one moves from East to West, in agreement with the predictions of a model in which (Neolithic) immigrants from the Near east contributed a large share of the alleles in the genome of current Europeans. Several tests suggest that probable departures from the admixture models, due to factors such as choice of the putative parental populations and more complex demographic scenarios, may have affected our main estimates only to a limited extent.

Key Words: human populations, admixture, Europe, Paleolithic, Neolithic


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
B. M. Henn, C. Gignoux, A. A. Lin, P. J. Oefner, P. Shen, R. Scozzari, F. Cruciani, S. A. Tishkoff, J. L. Mountain, and P. A. Underhill
Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa
PNAS, August 5, 2008; 105(31): 10693 - 10698.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
U Roostalu, I Kutuev, E-L Loogvali, E Metspalu, K Tambets, M Reidla, E. Khusnutdinova, E Usanga, T Kivisild, and R Villems
Origin and Expansion of Haplogroup H, the Dominant Human Mitochondrial DNA Lineage in West Eurasia: The Near Eastern and Caucasian Perspective
Mol. Biol. Evol., February 1, 2007; 24(2): 436 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Beja-Pereira, D. Caramelli, C. Lalueza-Fox, C. Vernesi, N. Ferrand, A. Casoli, F. Goyache, L. J. Royo, S. Conti, M. Lari, et al.
From the Cover: The origin of European cattle: Evidence from modern and ancient DNA
PNAS, May 23, 2006; 103(21): 8113 - 8118.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. Klopfstein, M. Currat, and L. Excoffier
The Fate of Mutations Surfing on the Wave of a Range Expansion
Mol. Biol. Evol., March 1, 2006; 23(3): 482 - 490.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
W. Haak, P. Forster, B. Bramanti, S. Matsumura, G. Brandt, M. Tanzer, R. Villems, C. Renfrew, D. Gronenborn, K. W. Alt, et al.
Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites
Science, November 11, 2005; 310(5750): 1016 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. Excoffier, A. Estoup, and J.-M. Cornuet
Bayesian Analysis of an Admixture Model With Mutations and Arbitrarily Linked Markers
Genetics, March 1, 2005; 169(3): 1727 - 1738.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.