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MBE Advance Access published online on March 19, 2004
Molecular Biology and Evolution, doi:10.1093/molbev/msh125
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved
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Accepted February 17, 2004
© 2004 Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2004; all rights reserved.

Original Articles

Reconciling the Numbers: ESTs versus Protein-Coding Genes

Anton Nekrutenko 1*

1 Dept. of Biochemistry and Molecular Biology, PennState University, University Park, PA 16802; The Huck Institute for Life Sciences, PennState University, University Park, PA 16802; Center for Comparative Genomics and Bioinformatics, PennState University, University Park, PA 16802

* To whom correspondence should be addressed. E-mail: nekrut{at}psu.edu.


  Abstract

The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9-14% of human and mouse expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only ~20,000 distinct protein-coding transcripts.


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