Skip Navigation



MBE Advance Access published online on October 31, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msh007
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
21/2/228    most recent
msh007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Boán, F.
Right arrow Articles by Gómez-Márquez, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boán, F.
Right arrow Articles by Gómez-Márquez, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Accepted August 20, 2003
© 2003 Society for Molecular Biology and Evolution

Original Articles

Birth and Evolutionary History of a Human Minisatellite

Francisco Boán 1, Miguel G. Blanco 1, Javier Quinteiro 1, Susana Mouriño 1, and Jaime Gómez-Márquez 1*

1 Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Santiago, 15782 Santiago de Compostela, Galicia, Spain

* To whom correspondence should be addressed. E-mail: bnjgm{at}usc.es.


  Abstract

One of the most exciting challenges in human biology is the understanding of how our genome was constructed during evolution. Here we explore the evolutionary history of the low polymorphic human minisatellite MsH42 and its flanking sequences. We show that the evolutionary birth of MsH42 took place within an intron, early in primate lineage evolution, more than 40 million years ago. Then, single-base pair changes and duplications/deletions of repeat blocks by mispairing were probably the main forces governing the generation of this minisatellite and its polymorphism throughout primate evolution. Moreover, we detected several phylogenetic footprints at both sides of MsH42. We believe that our findings will contribute to the understanding of low-variability minisatellite evolution.

Key Words: Minisatellite evolution, phylogenetic footprint, primates, human minisatellite MsH42


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.