MBE Advance Access published online on August 29, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg229
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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1 Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona, 85721
* To whom correspondence should be addressed. E-mail: hochman{at}email.arizona.edu.
Molecular evolutionary biologists usually assess the underlying spectrum of mutations within a bacterial genome by examining substitutions that occur at sites that are believed to be under no selective constraints. Alternatively, bacterial mutation rates can also be estimated in a variety of experimental systems. The two classes of changes occurring in DNA sequences - i.e., mutations and neutral substitutions - are, in theory, identical; however, the rates and patterns of mutations in bacteria, as inferred from sequence comparisons, often differ significantly from those derived experimentally. These differences have resulted in conflicting interpretations of the non-selective forces that affect mutation rates. Key Words:
mutation rates, nucleotide substitutions, bacterial evolution, E. coli, S. enterica
© 2003 Society for Molecular Biology and Evolution
Original Articles
Neutral Mutations and Neutral Substitutions in Bacterial Genomes
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