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MBE Advance Access published online on July 28, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg200
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted June 16, 2003
© 2003 Society for Molecular Biology and Evolution

Original Articles

Evidence for the Contribution of LTR Retrotransposons to C. elegans Gene Evolution

Eric W. Ganko 1*, Vikram Bhattacharjee 1, Paul Schliekelman 2, and John F. McDonald 1

1 Department of Genetics, University of Georgia, Athens, GA 30602 USA
2 Department of Statistics, University of Georgia, Athens, GA 30602 USA

* To whom correspondence should be addressed. E-mail: edog22{at}uga.edu.


  Abstract

LTR retrotransposons may be important contributors to host gene evolution since they contain regulatory and coding signals. In an effort to assess the possible contribution of LTR retrotransposons to C. elegans gene evolution, we searched upstream and downstream of LTR retrotransposon sequences for the presence of predicted genes. Sixty-three percent of LTR retrotransposon sequences (79/124) are located within 1 kb of a gene or within gene boundaries. Most gene-retrotransposon associations were located along the chromosome arms. Our results are consistent with the hypothesis that LTR retrotransposons have contributed to the structural and/or regulatory evolution of genes in C. elegans.

Key Words: C. elegans, LTR retrotransposon, gene evolution, genome evolution


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