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MBE Advance Access published online on August 29, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg198
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted June 5, 2003
© 2003 Society for Molecular Biology and Evolution

Original Articles

Intra- and Interspecific Variation of the CCR5 Gene in Higher Primates

Yun-wu Zhang 1, Oliver A. Ryder 1*, and Ya-ping Zhang 2

1 Center for Reproduction of Endangered Species, Zoological Society of San Diego, San Diego, CA 92112, USA
2 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Laboratory of Molecular Genetics, Yunnan University, Kunming, Yunnan 650091, China

* To whom correspondence should be addressed. E-mail: oryder{at}ucsd.edu.


  Abstract

We have evaluated the molecular evolution of the chemokine receptor CCR5 in primates. The chemokine receptor CCR5 serves as a major co-receptor for HIV/SIV infection. Knowledge of evolution of the CCR5 molecule and selection on the CCR5 gene may shed light on its functional role. The comparison of differences between intraspecific polymorphisms and interspecific fixed substitutions provides useful information regarding modes of selection during the course of evolution. There is marked polymorphism in the CCR5 gene sequence within different primate species, while sequence divergence between different species is small. By using contingency tests, we compared synonymous (SS) and nonsynonymous (NS) CCR5 mutations occurring within and between a broad range of primates. Our results demonstrate that CCR5 evolution did not follow expectations of strict neutrality at the level of the whole gene. The proportion of NS to SS at the intraspecific level was significantly higher than that observed at the interspecific level. These results suggest that most CCR5 NS polymorphisms are slightly deleterious. However, at domains more correlated with its known biological functions, there was no obvious evidence to support deviation from neutrality.

Key Words: CCR5, evolution, primates


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