MBE Advance Access published online on July 28, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg187
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Tokyo Institute of Technology, Faculty of Bioscience and Biotechnology, Department of Biological Sciences, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
* To whom correspondence should be addressed. E-mail: nokada{at}bio.titech.ac.jp.
Short interspersed nuclear elements (SINEs) are dispersed repetitive DNA sequences that are major components of all mammalian genomes. They have been described in almost all lineages of Euarchontoglires (rodents, rabbits, primates, flying lemurs and tree shrews), except in flying lemurs. Most SINE family members are composed of three distinct regions: a 5' tRNA-related region, a tRNA-unrelated region, and a short tandem repeat at the 3' end that is AT-rich. The newly discovered SINE family in Cynocephalus deviates from this common structure. All 30 SINE loci analyzed in this family lack a tRNA-unrelated region and are composed exclusively of tRNA-related elements. Therefore, this novel SINE structure, described for the first time in mammalian genomes, was designated as t-SINE. The t-SINE family exhibits a high copy number and is specific to flying lemurs. Three major t-SINE subfamilies could be distinguished on the basis of characteristic nucleotides, deletions, insertions and duplications. These sequence-specific characteristics within subfamilies and sub-subfamilies reveal that they are derived copies of distinct progenitors. We present evolutionary relationships between subfamilies, and compare relationships between the subfamilies and the isoleucine tRNA gene. t-SINE amplification occurred through multiple sources and is supposedly mobilized via the L1-encoded reverse transcriptase-dependent retrotranspositional mechanism in trans. Key Words:
t-SINE, tRNA-derived, subfamilies, multiple source gene model, Cynocephalus variegatus, Dermoptera
© 2003 Society for Molecular Biology and Evolution
Original Articles
Unique Mammalian tRNA-Derived Repetitive Elements in Dermopterans: The t-SINE Family and Its Retrotransposition through Multiple Sources
2 Museum Zoologi Bogor, Puslit Biologi-LIPI, Jl. Raya Bogor Jakarta Km 46, Cibinong 16911, Indonesia
3 Kitakyushu Museum and Institute of Natural History, Nishihonmachi 3-6-1, Yahatahigashiku, Kitakyushu 805-0061, Japan
4 Tokyo Institute of Technology, Faculty of Bioscience and Biotechnology, Department of Biological Sciences, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan; National Institute for Basic Biology, Department of Cell Biology, Nishigonaka 38, Myodaiji, Okazaki 444-8585 Aichi, Japan
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Tawari, I. K. M. Ali, C. Scott, M. A. Quail, M. Berriman, N. Hall, and C. G. Clark Patterns of Evolution in the Unique tRNA Gene Arrays of the Genus Entamoeba Mol. Biol. Evol., January 1, 2008; 25(1): 187 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Churakov, A. F.A. Smit, J. Brosius, and J. Schmitz A Novel Abundant Family of Retroposed Elements (DAS-SINEs) in the Nine-Banded Armadillo (Dasypus novemcinctus) Mol. Biol. Evol., April 1, 2005; 22(4): 886 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pelissier, C. Bousquet-Antonelli, L. Lavie, and J.-M. Deragon Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana Nucleic Acids Res., July 28, 2004; 32(13): 3957 - 3966. [Abstract] [Full Text] [PDF]
|
|