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MBE Advance Access published online on May 30, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg145
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted April 9, 2003
© 2003 Society for Molecular Biology and Evolution

Original Articles

The Effect of Positive Selection on a Sexual Reproduction Gene in Thalassiosira weissflogii (Bacillariophyta): Results Obtained from Maximum Likelihood and Parsimony-Based Methods

Ulf Sorhannus 1*

1 Department of Biology & Health Services, Edinboro University of Pennsylvania, Edinboro, Pennsylvania 16444, USA

* To whom correspondence should be addressed. E-mail: usorhannus{at}edinboro.edu.


  Abstract

Likelihood-based and parsimony-based methods were used to test for potential effects of positive selection on the sexually induced gene 1 (Sig1) in Thalassiosira weissflogii. The Sig-proteins are thought to play a role in mediating sperm-egg recognition during the sexual reproduction phase. The results obtained from parsimony-based analyses showed that none of the amino acid sites were influenced by positive selection. Maximum likelihood analyses indicated that positive selection was affecting a maximum of 7 and a minimum of 4 amino acid sites in the polypeptide derived from Sig1. It was concluded that the results obtained from the likelihood-based method are more reliable than those obtained from the parsimony-based approach. This is apparently the first study that has shown that reproductive proteins in unicellular eukaryotes are influenced by positive selection.

Key Words: Sexual reproduction gene, likelihood, parsimony, positive selection, synonymous substitution, nonsynonymous substitution


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