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MBE Advance Access published online on May 30, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg127
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted March 25, 2003
© 2003 Society for Molecular Biology and Evolution

Original Articles

Systematic Phylogenomic Evidence of en Bloc Duplication of the Ancestral 8p11.21-8p21.3 Like Region

Alexandre Vienne 1*, Jeffrey Rasmussen 1, Laurent Abi-Rached 2, Pierre Pontarotti 2, André Gilles 1

1 EA Biodiversité 2202, Université de Provence, Place V. Hugo, 13331 Marseille Cedex 3, France
2 INSERM U119, 27 Bd Leï Roure, 13009 Marseille, France

* To whom correspondence should be addressed. E-mail: avienne{at}up.univ-mrs.fr.


  Abstract

The genomes of many higher organisms, including plants and bony fish, frequently undergo polyploidisation and it has long been hypothesised that these, and other, large-scale genomic duplications played an important role in the major evolutionary transitions of our past. Here we build upon an early work to show that the human genomic region 8p11.21-8p21.3 has three paralogous regions on chromosomes 4, 5, and 10 that were produced by two rounds of duplications after the protostomian-deuterostomian split and before the actinopterygian-sarcopterygian split. We base our analysis on the phylogenetic reconstruction of the evolutionary history of 38 gene families located in these regions. Using an alignment centered around protein domains, three different phylogenetic methods, and divergence time estimation, this analysis gives more support in favor of two ancient polyploidisation events in the vertebrates ancestral genome.

Key Words: vertebrate evolution, 2R, paralogous regions, polyploidisation, diploidisation, mapping, time divergence


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