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MBE Advance Access published online on April 2, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg084
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted December 20, 2002
© 2003 Society for Molecular Biology and Evolution

Original Articles

Dinucleotide Repeats in the Drosophila and Human Genomes Have Complex, Length-Dependent, Mutation Processes

Peter Calabrese 1 Rick Durrett 2*

1 University of Southern California
2 Cornell University

* To whom correspondence should be addressed. E-mail: rtd1{at}cornell.edu.


  Abstract

We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting long microsatellites have a bias towards contractions.

Key Words: microsatellites, genome, human, Drosophila


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