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MBE Advance Access published online on April 2, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg066
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted December 9, 2002
© 2003 Society for Molecular Biology and Evolution

Original Articles

Directional Evolution of Size Coupled with Ascertainment Bias for Variation in Drosophila Microsatellites

William Amos 1, Carolyn M. Hutter 2, Malcolm D. Schug 3, Charles F. Aquadro 4*

1 Department of Zoology, University of Cambridge
2 Department of Molecular Biology and Genetics, Cornell University; Department of Epidemiology, University of Washington School of Public Health and Community Medicine
3 Department of Molecular Biology and Genetics, Cornell University; Department of Biology, University of North Carolina, Greensboro
4 Department of Molecular Biology and Genetics, Cornell University

* To whom correspondence should be addressed. E-mail: CFA1{at}CORNELL.EDU.


  Abstract

Species-specific differences in microsatellite locus length and ascertainment bias have both been proposed to explain differences in microsatellite variability and length usually observed when loci isolated in one species are used to survey variation in a related species. Here we provide a simple algebraic approach to independently estimate the contributions of true species-specific length differences and ascertainment bias. We apply this approach to the reciprocal-isolation microsatellite study of Hutter et al. (1998) and show contributions of both ascertainment bias and a true longer average microsatellite length in Drosophila melanogaster compared to D. simulans.

Key Words: Drosophila, microsatellites, ascertainment bias, directional evolution


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