MBE Advance Access published online on February 4, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg036
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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1 Institut Jacques Monod, UMR 7592, Dynamique du Génome et Evolution, CNRS, Universités PM Curie, D. Diderot, 2, Place Jussieu, 75252 PARIS, France
* To whom correspondence should be addressed. E-mail: anxo{at}ccr.jussieu.fr.
Two independent stationary P-related neogenes had been previously described in the Drosophila obscura species group and in the Drosophila montium species subgroup. In Drosophila melanogaster, P transposable elements can encode an 87 kDa transposase and a 66 kDa repressor, but the P-neogenes have only conserved the capacity to encode a 66 kDa repressor-like protein of specified by the three first exons. We have previously analyzed the genomic modifications associated with the transition of a P element into the montium P-neogene the coding capacity of which has been conserved for around 20 million years (Nouaud and Anxolabéhère 1997). Here we show that the P-neogene of some species of the montium subgroup presents a new structure involving the capture of an additional exon from a very distant P element sub-family. This additional exon is inserted either upstream or downstream of the first exon of the P-neogene. As a result of alternative splicing, these modified neogenes can produce, in addition to the repressor-like protein, a new protein which differs only by the NH2-terminal region. We hypothesize that this protein diversity within an organism results in a functional diversification due to the selective advantage associated with the domestication of the P-neogene in these species. Moreover, the autonomous P element which provides the additional exons is still present in the genome. Its nucleotide sequence is more than 45% distant to the previously defined P-type element (M-type, O-type, T-type) and defines a new P-type element sub-family referred to as the K-type. Key Words:
Key words: P-element, transposon, exon shuffling, molecular domestication, Drosophila montium subgroup
© 2003 Society for Molecular Biology and Evolution
Original Articles
Recurrent exon shuffling between distant P-element families
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