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MBE Advance Access published online on February 7, 2003
Molecular Biology and Evolution, doi:10.1093/molbev/msg021
Molecular Biology and Evolution © Society for Molecular Biology and Evolution 2003; all rights reserved
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Accepted October 9, 2002
© 2003 Society for Molecular Biology and Evolution

Original Articles

Positive Selection on an Acrosomal Sperm Protein, M7 Lysin, in three Species of the Mussel Genus Mytilus

Cynthia Riginos 1* John H. McDonald 2

1 Department of Biology, Box 90338, Duke University, Durham, NC 27708
2 Department of Biological Sciences, University of Delaware, Newark, DE 19716

* To whom correspondence should be addressed. E-mail: riginos{at}duke.edu.


  Abstract

Marine invertebrate sperm proteins are particularly interesting because they are characterized by positive selection and are likely to be involved in prezyogotic isolation and, thus, speciation. Here, we present the first survey of inter and intraspecific variation of a bivalve sperm protein among a group of species that regularly hybridize in nature. M7 lysin is found in sperm acrosomes of mussels and dissolves the egg vitelline coat, permitting fertilization. We sequenced multiple alleles of the mature protein-coding region of M7 lysin from allopatric populations of mussels in the Mytilus edulis species group (M. edulis, M. galloprovincialis, and M. trossulus). A significant McDonald-Kreitman test showed an excess of fixed amino acid replacing substitutions between species, consistent with positive selection. In addition, Kolmogorov-Smirnov tests showed significant heterogeneity in polymorphism to divergence ratios for both synonymous variation and combined synonymous and non-synonymous variation within M. galloprovincialis. These results indicate that there has been adaptive evolution at M7 lysin and, furthermore, shows that positive selection on sperm proteins can occur even when post-zygotic reproductive isolation is incomplete.

Key Words: Keywords: fertilization, gamete recognition, lysin, Mytilus, positive selection, sperm protein


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