Molecular Biology and Evolution, Vol 9, 654-665, Copyright © 1992 by Society for Molecular Biology and Evolution
BG Hall and PM Sharp
The DNA sequences of three genes--celC, crr, and gutB--have been determined
for each of 11 or 12 natural isolates of Escherichia coli from the ECOR
collection. These genes encode the phosphoenolpyruvate- dependent
phosphotransferase-system enzyme III proteins specific for beta-glucoside
sugars (celC), glucose (crr), and glucitol (gutB), respectively. There is
little evidence of recombination at or among these loci; among these
strains, relationships inferred from each gene are largely consistent with
each other and with the relationship inferred from multilocus enzyme
electrophoresis. DNA sequence diversity is similar for all three genes,
particularly when silent (synonymous) sites only are considered. This is
surprising because there is much stronger codon usage bias at crr than at
celC or gutB. The extent of divergence in the protein sequences encoded by
these three genes varies considerably. The constitutively expressed
glucose-specific enzyme is completely conserved. It is surprising that the
inducible glucitol- specific enzyme, which is functional, is more variable
than the cellobiose-specific enzyme, which is cryptic; the latter might be
expected to be under less (if any) purifying selection.
ORIGINAL ARTICLE
Molecular population genetics of Escherichia coli: DNA sequence diversity at the celC, crr, and gutB loci of natural isolates [published erratum appears in Mol Biol Evol 1992 Nov;9(6):1174]
Department of Biology, University of Rochester, New York 14627.
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