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MBE Advance Access originally published online on October 29, 2008
Molecular Biology and Evolution 2009 26(2):285-297; doi:10.1093/molbev/msn246
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© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

The Multiple Evolutionary Histories of Dioxygen Reductases: Implications for the Origin and Evolution of Aerobic Respiration

Celine Brochier-Armanet*,{dagger}, Emmanuel Talla{dagger},{ddagger} and Simonetta Gribaldo§

* Université de Provence, Aix-Marseille I, Marseille, France
{dagger} Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée (IF88), Marseille, France
{ddagger} Université de la Méditerranée, Aix-Marseille II, Marseille, France
§ Unité de Biologie Moléculaire Chez les Extremophiles, Département de Microbiologie, Institut Pasteur, Paris, France

E-mail: celine.brochier{at}ibsm.cnrs-mrs.fr.

Accepted for publication October 22, 2008.

Understanding the origin and evolution of cellular processes is fundamental to understand how biological activity has shaped the history of our planet. Among these, aerobic respiration is probably one of the most debated. We have applied a phylogenomics approach to investigate the origin and evolution of dioxygen reductases (O2Red), the key enzymes of aerobic respiratory chains. The distribution and phylogenetic analysis of the four types of O2Red (Cyt-bd and the A, B, and C families of heme–copper O2Red) from 673 complete bacterial and archaeal genomes show that these enzymes have very different evolutionary histories: Cyt-bd are of bacterial origin and were transferred to a few archaea; C-O2Red are of proteobacterial origin and were transferred to a few other bacteria; B-O2Red are of archaeal origin and were transferred to a few bacteria; and A-O2Red are the most ancient O2Red and were already present prior to the divergence of major present-day bacterial and archaeal phyla, thus before the emergence of Cyanobacteria and oxygenic photosynthesis. Implications for the origin and the evolution of aerobic respiration are discussed.

Key Words: dioxygen reductases • aerobic respiration • horizontal gene transfer • phylogenomics • cytochrome c oxidases • cytochrome bd

Andrew Roger, Associate Editor


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