Skip Navigation


MBE Advance Access originally published online on May 2, 2007
Molecular Biology and Evolution 2007 24(8):1622-1626; doi:10.1093/molbev/msm080
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
24/8/1622    most recent
msm080v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Osada, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Osada, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Inference of Expression-Dependent Negative Selection Based on Polymorphism and Divergence in the Human Genome

Naoki Osada

Department of Biomedical Resources, National Institute of Biomedical Innovation, Osaka, Japan

E-mail: nosada{at}nibio.go.jp.

Accepted for publication April 14, 2007.

There is a mounting evidence for the correlation between the gene expression pattern and sequence divergence. However, little is known about the relationship between the gene expression pattern and polymorphism. We compiled the gene expression, polymorphism, and divergence data from the public databases of the human genome. The ratios of nonsynonymous (A) to synonymous (S) substitutions in polymorphism and divergence in the human genome were strongly influenced by the expression pattern and breadth of genes and showed strong correlations. Among the tissues we analyzed, the brain-expressed genes have the smallest and the liver-expressed genes have the largest proportion of amino acid changes both in polymorphism and divergence. The analysis implies that negative selection is the primary factor affecting expression-dependent gene evolution and the prevalent but nonuniform distribution of slightly deleterious mutations in the genome. Although the genes under relaxed negative selection evolved faster than the other genes, these genes are even more liable to slightly deleterious mutations in the population. On the other hand, nonneutral mutations in the highly conservative genes, such as brain-expressed and housekeeping genes, are largely deleterious and eliminated before they enter the population.

Key Words: gene expression • human genome • slightly deleterious mutations • natural selection • McDonald–Kreitman test

Takashi Gojobori, Associate Editor


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Osada, S. Mano, and J. Gojobori
Quantifying dominance and deleterious effect on human disease genes
PNAS, January 20, 2009; 106(3): 841 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. P. Foxe, V.-u.-N. Dar, H. Zheng, M. Nordborg, B. S. Gaut, and S. I. Wright
Selection on Amino Acid Substitutions in Arabidopsis
Mol. Biol. Evol., July 1, 2008; 25(7): 1375 - 1383.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.