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MBE Advance Access originally published online on April 17, 2007
Molecular Biology and Evolution 2007 24(7):1458-1463; doi:10.1093/molbev/msm073
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Compensatory Change of Interacting Amino Acids in the Coevolution of Transcriptional Coactivator MBF1 and TATA-Box–Binding Protein

Qing-Xin Liu*,1, Naomi Nakashima-Kamimura{dagger},1, Kazuho Ikeo*, Susumu Hirose{dagger} and Takashi Gojobori*

* Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan
{dagger} Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan

E-mail: tgojobor{at}genes.nig.ac.jp.

Accepted for publication March 15, 2007.

To elucidate the transcriptional regulation in eukaryotic genome network, it is important to understand coevolution of transcription factors, transcriptional coactivators, and TATA-box–binding protein (TBP). In this study, coevolution of transcriptional coactivator multiprotein-bridging factor 1 and its interacting target TBP was first evaluated experimentally by examining if compensatory amino acid changes took place at interacting sites of both proteins. The experiments were conducted by identifying interaction sites and comparing the amino acids at these sites among different organisms. Here, we provide evidence for compensatory changes of transcription coactivator and its interacting target, presenting the 1st report that transcription coactivator may have undergone coevolution with TBP.

Key Words: compensatory change • coevolution • transcriptional coactivator • MBF1 • TBP

1 Equal contribution to this work.

Yoko Satta, Associate Editor


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