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MBE Advance Access originally published online on January 11, 2007
Molecular Biology and Evolution 2007 24(3):868-874; doi:10.1093/molbev/msm004
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Luísa Pereira*,{dagger}, João Gonçalves{ddagger}, Ricardo Franco-Duarte*, Júlia Silva{ddagger}, Tiago Rocha§, Christiane Arnold§, Martin Richards|| and Vincent Macaulay

* Instituto de Patologia e Imunologia Molecular da Universidade do Porto, (IPATIMUP), Porto, Portugal
{dagger} Medical Faculty, University of Porto, Portugal
{ddagger} Centro de Genética Humana Instituto Nacional de Saude Dr Ricardo Jorge, Lisboa, Portugal
§ Maternidade Dr Alfredo da Costa, Lisboa, Portugal
|| Institute of Integrative & Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
Department of Statistics, University of Glasgow, Glasgow, United Kingdom

E-mail: lpereira{at}ipatimup.pt.

Accepted for publication January 3, 2007.

The first complete mitochondrial DNA (mtDNA) sequences (~16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

Key Words: mtDNA • complete sequences • asthenozoospermia • association

Connie Mulligan, Associate Editor


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